Job Type: Permanent
Astex Pharmaceuticals is a world leader in innovative drug discovery and development. The company has successfully applied its proprietary Fragment-Based Drug Discovery platform to generate multiple new drug candidates that are progressing in clinical development. Successful collaborations have led to three launched oncology drugs (Kisqali partnered with Novartis, Balversa partnered with Janssen and Truqap partnered with AstraZeneca). Astex continues to grow and focuses on Neurological Disorders and Oncology.
The Opportunity
Astex has established a state of the art, in-house, cryo-EM facility, including two Glacios and one Krios transmission electron microscopes, a fully equipped cryo-EM sample preparation laboratory and extensive computing infrastructure. We have also developed custom data collection and processing workflows to facilitate the rapid generation and interpretation of cryo-EM structures for Structure- and Fragment- Based Drug Discovery.
Additionally, Astex is a member of the Cambridge cryo-EM consortium (providing access to two additional Krios microscopes) and has multiple collaborations with cryo-EM centres of excellence, including the MRC-LMB, the University of Cambridge, the University of Oxford and Monash University (Australia). Our continued commitment to develop our cryo-EM platform means we now have an exciting new role within our cryo-EM team for a cryo-EM software developer.
We are seeking a talented and highly innovative developer of cryo-EM single particle analysis algorithms who would like to embark on the challenge of developing novel, ligand-focused, data processing approaches to transform drug discovery using cryo-EM. You would be responsible for actively advancing the field of single particle analysis and implementing new image processing algorithms into webcryo, our proprietary, high-throughput, platform for cryo-EM data management, processing and visualisation.
Candidate profile
- PhD in mathematics, computer science or another relevant numerical/ computational discipline; alternatively, equivalent experience in relevant research
- Detailed knowledge of single particle analysis (SPA) image processing theory with proven experience in algorithm development for SPA
- Excellent knowledge of Python and familiarity with Git
- Excellent problem-solving skills
- Excellent team working and communication skills
- Ideally, familiarity with relational databases
Why Astex
We offer excellent training and career development opportunities as well as highly competitive salary and benefits package including hybrid working options to promote a flexible and inclusive work environment.
The company is situated 2.5 miles from Cambridge City centre. Cambridge Science Park has onsite sports facilities and excellent transport links to London.
At Astex we embrace diversity and equality of opportunity. We are committed to building an inclusive and diverse Company representing all backgrounds, harnessing industry-leading scientific innovation and behaviours.
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